Rumorville:  Three sets of casting calls are said to have gone out for General Hospital:

An actor, 25 to 35 years old, of Greek and Russian descent. His family is dysfunctional, and violent. This contract role begins in May.

An actress, 15 years old, Caucasian (who could possibly be the lost Quartermaine heir.) This contract role begins in April.

Two actors who are 30-50 years old, Caucasian and brothers. They have bloodlines to a well known family from the past. These contracts roles begin in June.
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Word is that Danny's inherited Cassadine family blood disorder, Beta-thalassemia, will be re-visited.

After all these years, the story of who fathered Sam with Alexis is expected to go forward.

Once Todd Manning leaves Port Charles (for OLTL) we may  not see him again until May).